A method of transmitting demodulation reference signals (DMRS) over one, three or five resource blocks (RBs) with Interleaved Frequency Division Multiple Access (IFDMA) from a wireless device to a wireless network node in a wireless network wherein Single Carrier Frequency Division Multiple Access (SC-OFDMA) is deployed in uplink, is provided. At least one of: a set of base sequences including thirty quadrature phase shifting keying, QPSK, sequences of length 6, 18 or 30 is determined, a demodulation reference signal sequence is derived from the determined set of base sequences, the demodulation reference signal sequence is multiplexed, and the multiplexed demodulation reference signal sequence is transmitted, by the wireless device, to the wireless network node.