- 专利标题: Bridged piperidine derivatives
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申请号: US16337348申请日: 2017-09-28
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公开(公告)号: US10899766B2公开(公告)日: 2021-01-26
- 发明人: Bjoern Bartels , Roland Jakob-Roetne , Anja Limberg , Werner Neidhart , Hasane Ratni , Michael Reutlinger , Jérôme Charles Sarie , Greta Vastakaite
- 申请人: Hoffmann-La Roche Inc.
- 申请人地址: US NJ Little Falls
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: US NJ Little Falls
- 代理机构: Genentech, Inc.
- 代理商 Richard G. A. Bone
- 优先权: EP16191512 20160929
- 国际申请: PCT/EP2017/074575 WO 20170928
- 国际公布: WO2018/060300 WO 20180405
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; C07D519/00 ; A61K31/55 ; A61K31/4196 ; A61P25/28 ; A61K31/551
摘要:
The present invention relates to a compound of formula (I), wherein R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen, lower alkoxy or lower alkoxy substituted by halogen; R may be the same or different, if n=2 or 3; n is 1, 2 or 3; m is 1, 2 or 3; Ar is a five or six membered heteroaryl group, selected from (II), (III), (IV) or (V) wherein R2 is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen or lower alkoxy; R3 is hydrogen or halogen; -( ) m-is —(CH2)m— or to pharmaceutically active acid addition salts thereof. The compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-in-farct dementia, dementia pugilistica or Down syndrome.
公开/授权文献
- US20200031831A1 BRIDGED PIPERIDINE DERIVATIVES 公开/授权日:2020-01-30
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