发明授权
- 专利标题: Pharmaceutical solid preparation comprising benzazepines and production method thereof
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申请号: US12665642申请日: 2008-06-20
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公开(公告)号: US10905694B2公开(公告)日: 2021-02-02
- 发明人: Shinsuke Nakagawa , Kai Suzuki , Tadashi Mukai
- 申请人: Shinsuke Nakagawa , Kai Suzuki , Tadashi Mukai
- 申请人地址: JP Osaka; JP Osaka; JP Osaka
- 专利权人: Shinsuke Nakagawa,Kai Suzuki,Tadashi Mukai
- 当前专利权人: Shinsuke Nakagawa,Kai Suzuki,Tadashi Mukai
- 当前专利权人地址: JP Osaka; JP Osaka; JP Osaka
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2007-163551 20070621
- 国际申请: PCT/JP2008/061686 WO 20080620
- 国际公布: WO2008/156217 WO 20081224
- 主分类号: A61K31/55
- IPC分类号: A61K31/55 ; A61K9/20 ; A61K9/16
摘要:
The subject invention provides a novel pharmaceutical solid preparation that has superior disintegration properties and excellent solubility, leading to sufficient absorbability of active ingredients through the gastrointestinal tract. The pharmaceutical solid preparation of the present invention comprises: (a) 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzoazepine and/or salt thereof; (b) hydroxypropylcellulose containing a hydroxypropoxyl group in an amount of 50% or greater; and (c) at least one member selected from the group consisting of carmellose, sodium carboxy methyl starch, crospovidone, and low substituted hydroxypropylcellulose with an average particle diameter of 30 to 70 μm, and a 90% cumulative particle diameter of 100 to 200 μm.
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