Invention Grant
- Patent Title: Antibody variants transmigrating the blood-brain barrier and uses thereof
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Application No.: US16468960Application Date: 2017-12-12
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Publication No.: US10906973B2Publication Date: 2021-02-02
- Inventor: Danica Stanimirovic , Traian Sulea , Kristin Kemmerich , David Wilson , Jennifer Stratton , Matthew Pollard , Adam Clarke
- Applicant: National Research Council of Canada , Cephalon, Inc.
- Applicant Address: CA Ottawa; US PA Frazer
- Assignee: National Research Council of Canada,Cephalon, Inc.
- Current Assignee: National Research Council of Canada,Cephalon, Inc.
- Current Assignee Address: CA Ottawa; US PA Frazer
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/IB2017/057844 WO 20171212
- International Announcement: WO2018/109663 WO 20180621
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K47/68
Abstract:
The present invention relates, in general, to polypeptides capable of transmigrating the blood-brain barrier, and uses thereof. More specifically, the present invention relates to polypeptides derived by site-directed mutagenesis of an existing antibody fragment and uses thereof, and methods of making such molecules. The polypeptides of the present invention show enhanced blood-brain barrier crossing and brain exposure levels in vitro and in vivo.
Public/Granted literature
- US20200095316A1 ANTIBODY VARIANTS TRANSMIGRATING THE BLOOD-BRAIN BARRIER AND USES THEREOF Public/Granted day:2020-03-26
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