Invention Grant
- Patent Title: Variant libraries of the immunological synapse and synthesis thereof
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Application No.: US15844395Application Date: 2017-12-15
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Publication No.: US10907274B2Publication Date: 2021-02-02
- Inventor: Anthony Cox , Siyuan Chen
- Applicant: Twist Bioscience Corporation
- Applicant Address: US CA San Francisco
- Assignee: Twist Bioscience Corporation
- Current Assignee: Twist Bioscience Corporation
- Current Assignee Address: US CA San Francisco
- Agency: Wilson Sonsini Goodrich & Rosati
- Main IPC: C40B40/08
- IPC: C40B40/08 ; C07K14/725 ; G01N33/574 ; G01N33/68 ; C12N15/10 ; G01N33/50 ; C40B30/04 ; A61K39/00

Abstract:
Disclosed herein are methods for the generation of highly accurate nucleic acid libraries encoding for predetermined variants of a nucleic acid sequence. The nucleic acid sequence may encode for all or part of a TCR or a TCR-binding antigen. The degree of variation may be complete, resulting in a saturated variant library, or less than complete, resulting in a non-saturating library of variants. The variant nucleic acid libraries described herein may designed for further processing by transcription or translation. The variant nucleic acid libraries described herein may be designed to generate variant RNA, DNA and/or protein populations. Further provided herein are method for identifying variant species with increased or decreased activities, with applications in regulating biological functions and the design of therapeutics for treatment or reduction of a disease, such as cancer.
Public/Granted literature
- US20180171509A1 VARIANT LIBRARIES OF THE IMMUNOLOGICAL SYNAPSE AND SYNTHESIS THEREOF Public/Granted day:2018-06-21
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