- 专利标题： Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid
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申请号： US16619299申请日： 2018-05-15
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公开(公告)号： US10913747B2公开(公告)日： 2021-02-09
- 发明人: Ottorino De Lucchi , Pierluigi Padovan , Elena Brasola
- 申请人： F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
- 申请人地址： IT Montecchio Maggiore
- 专利权人： F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
- 当前专利权人： F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
- 当前专利权人地址： IT Montecchio Maggiore
- 代理机构： Lucas & Mercanti, LLP
- 优先权： EP17179524 20170704
- 国际申请： PCT/EP2018/062508 WO 20180515
- 国际公布： WO2019/007578 WO 20190110
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; B01J27/08
摘要：
Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.
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