Embodiments include systems with active sound canceling properties, fenestration units with active sound canceling properties, retrofit units with active sound canceling properties and related methods. In an embodiment a system can include a sound cancellation device include a sensing element to detect vibration of a transparent pane and/or a sound input device configured to detect sound incident on the transparent pane, as well as a vibration generator configured to vibrate the transparent pane and a sound cancellation control module. The sound cancellation control module can evaluate the detected vibration of the transparent pane at two or more discrete frequency bands. The sound cancellation control module can cause the vibration generator to vibrate the transparent pane causing destructive interference with sound waves at the two or more discrete frequency bands. Other embodiments are also included herein.