A signal transmission method and related timing controller, source driver and display device are disclosed. The method includes scrambling a signal to be transmitted by a transmitting unit to obtain a scrambled signal. Each frame of the scrambled signal includes at least one first identification signal sequentially arranged in time domain, and a number of the first identification signals in the scrambled signal is equal to a number of the first identification signals in the scrambled signals of other transmitting units in the plurality of transmitting units. The method includes transmitting the scrambled signal to a corresponding receiving unit, where the first identification signal is configured to indicate linear feedback shift registers of the transmitting unit and the corresponding receiving unit to perform a reset operation, and after each collective reset operation is completed, the corresponding receiving unit outputs a display signal to the display panel.