An apparatus includes at least one processing device configured to obtain samples of an input signal to be amplified and, in real-time, pre-distort at least some of the samples using pre-distortion values from at least one lookup table. The pre-distorted samples are to be converted into an analog signal that is amplified by at least one power amplifier. The pre-distortion values at least partially compensate for a non-linear operation of the at least one power amplifier. The at least one processing device is also configured to compare an output signal generated by the at least one power amplifier to an expected signal to identify errors between the output and expected signals. The at least one processing device is further configured to update one or more pre-distortion values in the at least one lookup table based on the identified errors.