- 专利标题： 3-(1H-pyrazol-4-yl)pyridine allosteric modulators of the M4 muscarinic acetylcholine receptor
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申请号： US16674546申请日： 2019-11-05
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公开(公告)号： US10933056B2公开(公告)日： 2021-03-02
- 发明人: John J. Acton, III , Jianming Bao , Melissa Egbertson , Xiaolei Gao , Scott T. Harrison , Sandra L. Knowles , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Zhaoyang Meng , Michael T. Rudd , Oleg B. Selyutin , David M. Tellers , Ling Tong , Jenny Miu-Chun Wai
- 申请人： Merck Sharp & Dohme Corp. , MSD R&D (CHINA) CO., LTD.
- 申请人地址： US NJ Rahway; CN Shanghai
- 专利权人： Merck Sharp & Dohme Corp.,MSD R&D (CHINA) CO., LTD.
- 当前专利权人： Merck Sharp & Dohme Corp.,MSD R&D (CHINA) CO., LTD.
- 当前专利权人地址： US NJ Rahway; CN Shanghai
- 代理商 J. Eric Thies; John C. Todaro
- 优先权： WOPCT/CN2015/098384 20151223
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D405/14 ; C07D471/04 ; A61K31/4439 ; A61P25/28 ; A61P25/18 ; A61P25/16 ; A61K31/437
摘要：
The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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