Systems, methods, and devices, including computer-readable media, for reducing medication side effects using digital therapeutics. In some implementations, a system analyzes tracking data, user data, and medication data for various users to determine a degree to which different digital therapeutics program parameters reduce a likelihood or severity of undesired effects of medications. The system generates data that associates the parameters of the digital therapeutics programs with effects of the medications. The system receives data indicating a medication prescribed for a user of a mobile device and, based on the generated data, selects one or more digital therapeutics program parameters to activate or adjust a particular digital therapeutic program to provide interactions to the user.