Invention Grant
- Patent Title: Apelin polypeptides
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Application No.: US15317911Application Date: 2015-06-10
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Publication No.: US10941182B2Publication Date: 2021-03-09
- Inventor: Jerry Ryan Holder , Gayathri Swaminath , Michael J. Frohn , Brian Alan Lanman , Anthony B. Reed , Leslie P. Miranda , John G. Allen , Alexander J. Pickrell , Aaron C. Siegmund , Lewis D. Pennington , Bryant Yang
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Lisa E. Alexander
- International Application: PCT/US2015/035205 WO 20150610
- International Announcement: WO2015/191781 WO 20151217
- Main IPC: C07K7/08
- IPC: C07K7/08 ; A61K38/10 ; C07K14/47 ; A61K47/54 ; A61K47/60 ; A61K38/00
Abstract:
The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
Public/Granted literature
- US20170107255A1 APELIN POLYPEPTIDES Public/Granted day:2017-04-20
Information query
