发明授权
- 专利标题: Apelin polypeptides
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申请号: US15317911申请日: 2015-06-10
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公开(公告)号: US10941182B2公开(公告)日: 2021-03-09
- 发明人: Jerry Ryan Holder , Gayathri Swaminath , Michael J. Frohn , Brian Alan Lanman , Anthony B. Reed , Leslie P. Miranda , John G. Allen , Alexander J. Pickrell , Aaron C. Siegmund , Lewis D. Pennington , Bryant Yang
- 申请人: AMGEN INC.
- 申请人地址: US CA Thousand Oaks
- 专利权人: AMGEN INC.
- 当前专利权人: AMGEN INC.
- 当前专利权人地址: US CA Thousand Oaks
- 代理商 Lisa E. Alexander
- 国际申请: PCT/US2015/035205 WO 20150610
- 国际公布: WO2015/191781 WO 20151217
- 主分类号: C07K7/08
- IPC分类号: C07K7/08 ; A61K38/10 ; C07K14/47 ; A61K47/54 ; A61K47/60 ; A61K38/00
摘要:
The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
公开/授权文献
- US20170107255A1 APELIN POLYPEPTIDES 公开/授权日:2017-04-20
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