![Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3- fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use](/docs/US/2021-03-23/US10954234B2/abs.jpg.600x600.jpg)
- Patent Title: Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3- fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
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Application No.: US16443515Application Date: 2019-06-17
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Publication No.: US10954234B2Publication Date: 2021-03-23
- Inventor: Cheol Keun Chung , Jie Xu , Hans Iding , Kyle Clagg , Michael Dalziel , Alec Fettes , Francis Gosselin , Ngiap-Kie Lim , Andrew McClory , Haiming Zhang , Paroma Chakravarty , Karthik Nagapudi , Sarah Robinson
- Applicant: Genentech, Inc. , Hoffman-La Roche, Inc.
- Applicant Address: US CA South San Francisco; US NJ Little Falls
- Assignee: Genentech, Inc.,Hoffman-La Roche, Inc.
- Current Assignee: Genentech, Inc.,Hoffman-La Roche, Inc.
- Current Assignee Address: US CA South San Francisco; US NJ Little Falls
- Agent Kevin M. Clark
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D403/14 ; A61P35/00 ; A61P35/04
![Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3- fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use](/abs-image/US/2021/03/23/US10954234B2/abs.jpg.150x150.jpg)
Abstract:
Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.
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