A surgical instrument comprising a housing, a drive system configured to generate rotary motion, an elongate shaft, and an end effector is disclosed. The end effector comprises a first jaw, a second jaw, and a fastener cartridge. The fastener cartridge comprises fasteners, a drive screw configured to rotate about a drive axis, and a firing member configured to move through a firing stroke. The firing member comprises a first cam surface configured to engage the first jaw and a second cam surface configured to engage the second jaw. The fastener cartridge further comprises a sled translatable within the fastener cartridge by the firing member during the firing stroke and a plurality of fastener drivers configured to rotate about an axis orthogonal to the drive axis in response to the translation of the sled. The plurality of fastener drivers deploy the fasteners by way of a rotational motion.