- 专利标题: Process for preparation of benzylic amides
-
申请号: US16480407申请日: 2018-01-16
-
公开(公告)号: US10961213B2公开(公告)日: 2021-03-30
- 发明人: Martin John McLaughlin , Karsten Koerber , Birgit Gockel , Devendra Vyas , Arun Narine
- 申请人: BASF SE
- 申请人地址: DE Ludwigshafen am Rhein
- 专利权人: BASF SE
- 当前专利权人: BASF SE
- 当前专利权人地址: DE Ludwigshafen am Rhein
- 代理机构: Marshall, Gerstein & Borun LLP
- 优先权: IN201721002825 20170125,EP17155685 20170210
- 国际申请: PCT/EP2018/050937 WO 20180116
- 国际公布: WO2018/137959 WO 20180802
- 主分类号: C07D307/79
- IPC分类号: C07D307/79
摘要:
The present invention relates to a process for preparing benzylic amides of formula I wherein the variables have the meaning as defined in the description, by reductive amidation of a nitrile of formula II wherein the variables have the meanings given for formula I, with an activated carbonyl compound of formula III, and which nitrile is obtained by reaction of a compound of formula IV with a halogen compound of formula V, wherein X is a halogen atom, preferably bromo, which halogen compound V in turn is obtained by Sandmeyer reaction of an aniline derivative of formula VI novel compounds of formula I, and processes for preparing compounds of formula XII wherein the variables have the meaning as defined in the description by condensing compounds of formula I with compounds of formula X and subjecting the resulting α,β-unsaturated ketone of formula XI to a reaction with hydroxylamine to yield compounds of formula XII.
公开/授权文献
- US20190382362A1 PROCESS FOR PREPARATION OF BENZYLIC AMIDES 公开/授权日:2019-12-19
信息查询