Invention Grant
- Patent Title: Process for preparation of benzylic amides
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Application No.: US16480407Application Date: 2018-01-16
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Publication No.: US10961213B2Publication Date: 2021-03-30
- Inventor: Martin John McLaughlin , Karsten Koerber , Birgit Gockel , Devendra Vyas , Arun Narine
- Applicant: BASF SE
- Applicant Address: DE Ludwigshafen am Rhein
- Assignee: BASF SE
- Current Assignee: BASF SE
- Current Assignee Address: DE Ludwigshafen am Rhein
- Agency: Marshall, Gerstein & Borun LLP
- Priority: IN201721002825 20170125,EP17155685 20170210
- International Application: PCT/EP2018/050937 WO 20180116
- International Announcement: WO2018/137959 WO 20180802
- Main IPC: C07D307/79
- IPC: C07D307/79

Abstract:
The present invention relates to a process for preparing benzylic amides of formula I wherein the variables have the meaning as defined in the description, by reductive amidation of a nitrile of formula II wherein the variables have the meanings given for formula I, with an activated carbonyl compound of formula III, and which nitrile is obtained by reaction of a compound of formula IV with a halogen compound of formula V, wherein X is a halogen atom, preferably bromo, which halogen compound V in turn is obtained by Sandmeyer reaction of an aniline derivative of formula VI novel compounds of formula I, and processes for preparing compounds of formula XII wherein the variables have the meaning as defined in the description by condensing compounds of formula I with compounds of formula X and subjecting the resulting α,β-unsaturated ketone of formula XI to a reaction with hydroxylamine to yield compounds of formula XII.
Public/Granted literature
- US20190382362A1 PROCESS FOR PREPARATION OF BENZYLIC AMIDES Public/Granted day:2019-12-19
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