Invention Grant
- Patent Title: TGF beta receptor antagonists
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Application No.: US16475413Application Date: 2018-01-03
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Publication No.: US10961239B2Publication Date: 2021-03-30
- Inventor: Robert M. Borzilleri , Upender Velaparthi , Chetan Padmakar Darne , Peiying Liu , Manjunatha Narayana Rao Kamble , Balaji Seshadri , Raju Mannoori , Hasibur Rahaman , Jayakumar Sankara Warrier
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agent Elliott Korsen
- International Application: PCT/US2018/012132 WO 20180103
- International Announcement: WO2018/132279 WO 20180719
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D401/14 ; C07D471/04 ; A61K45/06 ; C07K16/28
Abstract:
The invention relates generally to compounds of formula (I) that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
Public/Granted literature
- US20190337942A1 TGF BETA RECEPTOR ANTAGONISTS Public/Granted day:2019-11-07
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