An active rotary inertia driver system includes an output support, a drive assembly and a rotary inertia plate. The output support includes a partition plate and a housing. The partition plate is fixed on an inner wall of the housing, and the housing is connected with a controlled structure. One end of the drive assembly is fixed on the housing and connected to one end of an output shaft. The other end of the drive assembly is fixed on the partition plate. The other end of the output shaft extends out of the housing and connected to the rotary inertia plate. The rotary inertia plate is a disc or a ring with a preset mass.