The present disclosure provides a method and a device in a first node and a base station for wireless communication. A first node transmits K1 first-type reference signal(s), and operates a first radio signal and a second radio signal; the K1 first-type reference signal(s) is(are) transmitted by K1 first-type antenna port set(s) respectively, a target antenna port set is a first-type antenna port set in the K1 first-type antenna port set(s); a first antenna port set and a second antenna port set are respectively used for transmitting the first radio signal and the second radio signal. The disclosure makes it practical for the first node to simultaneously operate radio signals transmitted from different transmitters in beamforming scenarios by connecting a first antenna port set and a second antenna port set with a target antenna port set, thereby improving the reception and transmission efficiency and the entire performance of the system.