Systems and methods are disclosed for utilizing sender-recipient pair data to establish sender-level trust in future communication. One method comprises receiving raw communication data over a network and testing the received raw communication data against trained machine learning data to predict whether the raw communication data is associated with expected communication data. The raw communication data is sorted for expected communication data, which is further analyzed for sender-recipient pair data and assigned an expected communication pair data score. Senders associated with an expected communication pair data score that meets or exceeds a threshold are labeled and stored in a database as trusted. As a result of the sender-recipient pair analysis, recipients at-risk for being scammed can be identified, senders misidentified as spammers can be properly classified, and machine learning techniques utilized for analyzing raw communication data can be fine-tuned.