A self-priming water turbine-driven reel sprinkler irrigation machine includes a framework, a plug board, a reel, a PE pipe, a water turbine driving device, a sprinkler wagon, and a self-priming device. The framework comprises an underframe, a reel support frame, a plug board support frame, and a wheel assembly. A bottom portion of the underframe is provided with an underframe rotary device, and the underframe rotary device comprises a rotary bearing and a chassis support member. An inner ring of the rotary bearing is fixedly mounted to the underframe, and an outer ring of the rotary bearing is fixedly mounted and connected to the chassis support member. A telescopic front support is disposed at a front part of the underframe. The wheel assembly comprises a wheel support beam, a wheel, and a wheel lifting hydraulic cylinder. The self-priming device comprises a water pump, a pumping hose, and a filtering mechanism.