- 专利标题： Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
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申请号： US16897905申请日： 2020-06-10
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公开(公告)号： US10981892B2公开(公告)日： 2021-04-20
- 发明人: Anne-Marie Beausoleil , Ryan Hudson
- 申请人： Unity Biotechnology, Inc.
- 申请人地址： US CA South San Francisco
- 专利权人： Unity Biotechnology, Inc.
- 当前专利权人： Unity Biotechnology, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： Bozicevic, Field & Francis llp
- 代理商 Rudy J. Ng
- 主分类号： C07F9/6509
- IPC分类号： C07F9/6509 ; C07D401/12 ; A61P11/00 ; A61P9/10 ; A61P27/00 ; A61P35/00 ; C07D401/10 ; C07D401/14 ; C07D403/10
摘要：
The aryl sulfonamide compounds of this invention have powerful and cell-type specific Bcl inhibitory activity. Selected compounds in this class promote apoptosis in senescent cells, and are being developed for treating senescent-related conditions. Selected compounds in this class promote apoptosis in cancer cells, and can be developed as chemotherapeutic agents.
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