Invention Grant
- Patent Title: 5-(pyridin-3-yl)oxazole allosteric modulators of the M4 muscarinic acetylcholine receptor
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Application No.: US16621943Application Date: 2018-06-22
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Publication No.: US10981902B2Publication Date: 2021-04-20
- Inventor: Jianming Bao , Timothy J. Henderson , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Meng Na , Michael T. Rudd , David M. Tellers , Ling Tong
- Applicant: Merck Sharp & Dohme Corp. , MERCK R&D (CHINA) CO., LTD.
- Applicant Address: US NJ Rahway; CN Shanghai
- Assignee: Merck Sharp & Dohme Corp.,MERCK R&D (CHINA) CO., LTD.
- Current Assignee: Merck Sharp & Dohme Corp.,MERCK R&D (CHINA) CO., LTD.
- Current Assignee Address: US NJ Rahway; CN Shanghai
- Agent J. Eric Thies; John C. Todaro
- Priority: WOPCT/CN2017/090386 20170627
- International Application: PCT/US2018/038892 WO 20180622
- International Announcement: WO2019/005589 WO 20190103
- Main IPC: C07D413/14
- IPC: C07D413/14 ; C07D471/04 ; C07D487/04
Abstract:
The present invention is directed to 5-(pyridine-3-yl)oxaxole compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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