The present disclosure provides a signal processing method and device. The method includes: sending a first data signal and receiving a second data signal in a first Resource Block (RB) of a first subframe; and further sending a first reference signal according to first reference information and receiving a second reference signal according to second reference information in the first RB, where: the first reference information is different from the second reference information; the first reference information includes: a time-frequency resource location occupied by the first reference signal, and sequence information of the first reference signal; and the second reference information includes: a time-frequency resource location occupied by the second reference signal, and sequence information of the second reference signal. The present disclosure ensures correct receiving of the reference signal.