A display panel and a driving method thereof, and a display device are disclosed. The display panel includes: a pixel region, including a first pixel region and a second pixel region located around the first pixel region, the first pixel region and the second pixel region each including a plurality of pixels; a photosensitive layer, located at least in the second pixel region; a cover plate, on a side of the pixel region for displaying, and the cover plate including a light transmission region and a light shielding layer surrounding the light transmission region. The light shielding layer coincides with at least a portion of the second pixel region in a direction perpendicular to the cover plate, and the photosensitive layer is configured to determine a position of the light transmission region.