A system and method of DFT-S-OFDM modulation is provided that uses a set of frequency domain patterns. For a given transmitter, for a set of DFT-S-OFDM symbols, the frequency domain pattern changes according to a time domain hopping pattern. Advantageously, the time domain hopping patterns are defined to allow only a certain amount of overlap, for example for only one DFT-S-OFDM symbol, between any two time domain hopping patterns. This functions to reduce the effect of a collision, when two transmitters use the same frequency pattern, they will do so only for part of the overall transmission. Optionally, frequency domain spectral spreading is used in the transmitter. This can further reduce the PAPR. In the receiver, successive interference cancellation may be employed to reduce the effect of colliding transmissions.