The present invention disclosed a lubricant system and methods of use. Said lubricant system comprises siloxane polymers with viscosity greater than 100 centistokes and cross-linking agents that can promote siloxane polymers curing rapidly in ambient conditions. The lubricant system comprises further hydroxy siloxane polymers, siloxane coupling agent, catalyst and volatile carrier solvents. The surfaces of medical devices are coated at least once, a solid lubrication film can be quickly formed, and the film has a very excellent lubricating performance and wide applications. The methods of use are simple, easy to implement and control, and is particularly suitable for rapid automatic production lines, and thus is of great economic value.