发明授权
- 专利标题： 1,3-dihydro-1,4-benzodiazepine-2-thiones for the treatment of CNS related diseases
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申请号： US16399134申请日： 2019-04-30
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公开(公告)号： US11021448B2公开(公告)日： 2021-06-01
- 发明人: Alexander Flohr
- 申请人： Hoffmann-La Roche Inc.
- 申请人地址： US NJ Little Falls
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Little Falls
- 代理商 Mark D. Kafka
- 优先权： EP16196725 20161101
- 主分类号： C07D243/24
- IPC分类号： C07D243/24 ; C07D243/22 ; C07D401/04 ; A61P25/28 ; A61P25/18
摘要：
The present invention provides compounds that are muscarinic M1 receptor positive allosteric modulators (PAM) and useful in the treatment of diseases, mediated by the muscarinic M1 receptor, such as Alzheimer's disease, cognitive impairment, schizophrenia, pain or sleep disorders, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances.
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