- 专利标题： Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
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申请号： US16867835申请日： 2020-05-06
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公开(公告)号： US11028104B2公开(公告)日： 2021-06-08
- 发明人: Michael Bader , Edgar Specker , Susann Matthes , Anja Schütz , Keven Mallow , Maik Grohmann , Marc Nazaré
- 申请人： MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN , FORSCHUNGSVERBUND BERLIN E.V.
- 申请人地址： DE Berlin; DE Berlin
- 专利权人： MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN,FORSCHUNGSVERBUND BERLIN E.V.
- 当前专利权人： MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN,FORSCHUNGSVERBUND BERLIN E.V.
- 当前专利权人地址： DE Berlin; DE Berlin
- 代理机构： Norris McLaughlin, P.A.
- 优先权： EP16181667 20160728
- 主分类号： A61P1/12
- IPC分类号： A61P1/12 ; A61P3/00 ; A61P11/00 ; A61P19/00 ; A61P25/00 ; A61P35/00 ; C07D519/00
摘要：
The invention relates to a xanthine derivative defined by chemical formula I or a salt thereof, its use as a medicament, especially for use in the treatment of serotonin-related diseases or disorders, and a pharmaceutical preparation comprising the xanthine derivative. The novel xanthine compounds are capable of inhibiting tryptophan hydroxylases (TPH) involved in the biosynthesis of serotonin and are effective in influencing the serotonin level in the body.
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