Invention Grant
- Patent Title: Antisense oligonucleotide controlling expression amount of TDP-43 and use thereof
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Application No.: US16630141Application Date: 2018-07-06
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Publication No.: US11028390B2Publication Date: 2021-06-08
- Inventor: Yoshitaka Nagai , Kazuhiro Maeta , Toshihide Takeuchi , Masahiro Neya , Tsuyoshi Fujihara , Seiji Matsuda , Gen Sobue , Shinsuke Ishigaki , Kentaro Sahashi
- Applicant: OSAKA UNIVERSITY , KNC LABORATORIES CO., LTD. , Aichi Medical University
- Applicant Address: JP Suita; JP Kobe; JP Nagakute
- Assignee: OSAKA UNIVERSITY,KNC LABORATORIES CO., LTD.,Aichi Medical University
- Current Assignee: OSAKA UNIVERSITY,KNC LABORATORIES CO., LTD.,Aichi Medical University
- Current Assignee Address: JP Suita; JP Kobe; JP Nagakute
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: JPJP2017-134890 20170710
- International Application: PCT/JP2018/025792 WO 20180706
- International Announcement: WO2019/013141 WO 20190117
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N15/11 ; C07H21/02 ; C07H21/04 ; C12N15/113 ; A61P25/28 ; A61K31/712
Abstract:
The present invention provides a suppression type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in any of SEQ ID NOs: 2-4, and a promotion type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in SEQ ID NO: 5.
Public/Granted literature
- US20200165610A1 ANTISENSE OLIGONUCLEOTIDE CONTROLLING EXPRESSION AMOUNT OF TDP-43 AND USE THEREOF Public/Granted day:2020-05-28
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