- 专利标题： Phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and use thereof
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申请号： US16786710申请日： 2020-02-10
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公开(公告)号： US11040952B2公开(公告)日： 2021-06-22
- 发明人: Youhong Hu , Jianping Zuo , Dong Lu , Li Yang , Limin Zeng , Feifei Liu , Yunzhe Zhang , Wuhong Chen , Xiankun Tong
- 申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- 申请人地址： CN Shanghai
- 专利权人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- 当前专利权人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- 当前专利权人地址： CN Shanghai
- 代理机构： Reinhart Boerner Van Deuren P.C.
- 优先权： CN201710681892.X 20170810
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; A61P31/20 ; C07D401/14 ; C07D405/14 ; C07D413/14
摘要：
Provided are a phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and a use thereof; the structure of said phthalazinone compound is as represented by formula I; the compound of said formula I is targeted to a viral nucleocapsid; it can inhibit the replication of a virus by means of interference of the viral nucleocapsid, has a potent activity for inhibiting HBV DNA replication and a good liver targeting, can stably exist and enrich in the liver, and is a new and effective anti-HBV inhibitor.