Invention Grant
- Patent Title: Alkylphenyl compounds
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Application No.: US16636670Application Date: 2018-08-08
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Publication No.: US11046646B2Publication Date: 2021-06-29
- Inventor: Alaric J. Dyckman , Ling Li , John L. Gilmore
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agent Gary Greenblatt
- International Application: PCT/US2018/045691 WO 20180808
- International Announcement: WO2019/032632 WO 20190214
- Main IPC: C07D207/04
- IPC: C07D207/04 ; A61K31/40 ; A61P1/00 ; C07D207/16

Abstract:
Disclosed are compounds of Formula (I): (I) or a salt thereof, wherein: X is —CH2— or —C(O)—; R1 is —OH or —OP(O)(OH)2; L is a bond, —CH2—, or —C(O)—; R2 is n-C6-8 alkyl; each R3 is independently selected from Cl and —CH3; and n is zero, 1, or 2; provided that if X is —CH2—, then L is —CH2— or —C(O)—. Also disclosed are methods of using such compounds as selective agonists for G protein coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
Public/Granted literature
- US20210147357A1 ALKYLPHENYL COMPOUNDS Public/Granted day:2021-05-20
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