- 专利标题： Compound for selectively inhibiting kinase and use thereof
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申请号： US16474991申请日： 2017-12-29
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公开(公告)号： US11046684B2公开(公告)日： 2021-06-29
- 发明人: Jianyu Liu , Haidong Zhang
- 申请人： SHANGHAI ZHEYE BIOTECHNOLOGY LIMITED-LIABILITY COMPANY
- 申请人地址： CN Shanghai
- 专利权人： SHANGHAI ZHEYE BIOTECHNOLOGY LIMITED-LIABILITY COMPANY
- 当前专利权人： SHANGHAI ZHEYE BIOTECHNOLOGY LIMITED-LIABILITY COMPANY
- 当前专利权人地址： CN Shanghai
- 代理机构： Marshall, Gerstein & Borun LLP
- 优先权： CN201710000367.7 20170102
- 国际申请： PCT/CN2017/120224 WO 20171229
- 国际公布： WO2018/121774 WO 20180705
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61P35/00
摘要：
Provided are a compound of formula (I), a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof, use thereof as a selective inhibitor for FGFR4 kinase and use thereof in manufacturing a medicament or pharmaceutical composition for treating diseases due to FGFR4 or FGF19. The compound disclosed by the invention has selective and significant inhibitory activities against FGFR4, and has wide application prospect in the field of tumor treatment.
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