- 专利标题： 2,2-difluorodioxolo A2A receptor antagonists
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申请号： US14914843申请日： 2014-08-25
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公开(公告)号： US11046714B2公开(公告)日： 2021-06-29
- 发明人: Ali Amjad , Gioconda V. Gallo , Timothy J. Henderson , Rongze Kuang , Yeon-Hee Lim , Michael Man-Chu Lo , Edward Metzger , Manuel de Lera Ruiz , Andrew Stamford , Paul Tempest , Brent Whitehead , Heping Wu
- 申请人： Merck Sharp & Dohme Corp. , Ali Amjad , Gioconda V. Gallo , Timothy J. Henderson , Rongze Kuang , Yeon-Hee Lim , Michael Man-Chu Lo , Edward Metzger , Manuel de Lera Ruiz , Andrew Stamford , Paul Tempest , Brent Whitehead , Heping Wu
- 申请人地址： US NJ Rahway; US NJ Edison; US NJ Berkely Heights; US MA Natick; US NJ Green Brook; US NJ Piscataway; US NJ Rahway; US MD Laurel; US PA Perkasie; US NJ Morristown; CN Shanghai; US NJ Morristown; US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.,Ali Amjad,Gioconda V. Gallo,Timothy J. Henderson,Rongze Kuang,Yeon-Hee Lim,Michael Man-Chu Lo,Edward Metzger,Manuel de Lera Ruiz,Andrew Stamford,Paul Tempest,Brent Whitehead,Heping Wu
- 当前专利权人： Merck Sharp & Dohme Corp.,Ali Amjad,Gioconda V. Gallo,Timothy J. Henderson,Rongze Kuang,Yeon-Hee Lim,Michael Man-Chu Lo,Edward Metzger,Manuel de Lera Ruiz,Andrew Stamford,Paul Tempest,Brent Whitehead,Heping Wu
- 当前专利权人地址： US NJ Rahway; US NJ Edison; US NJ Berkely Heights; US MA Natick; US NJ Green Brook; US NJ Piscataway; US NJ Rahway; US MD Laurel; US PA Perkasie; US NJ Morristown; CN Shanghai; US NJ Morristown; US NJ Rahway
- 代理商 Janet E. Fair; Catherine D. Fitch
- 优先权： WOPCT/CN2013/082560 20130829
- 国际申请： PCT/US2014/052442 WO 20140825
- 国际公布： WO2015/031221 WO 20150305
- 主分类号： C07D519/00
- IPC分类号： C07D519/00 ; C07D491/147
摘要：
The present invention is directed to 2,2-difluorodioxolo compounds that are antagonists of A2A receptor. The present invention is also directed to uses of the 2,2-difluorodioxolo compounds described herein in the potential treatment or prevention of neurological disorders and diseases in which A2A receptor are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds and to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which A2A receptors are involved.
公开/授权文献
- US20160214997A1 2,2-DIFLUORODIOXOLO A2A RECEPTOR ANTAGONISTS 公开/授权日：2016-07-28
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