Systems and methods for synchronization and streaming of workspace contents with audio for collaborative virtual, augmented, and mixed reality (xR) applications are described. In an embodiment, an Information Handling System (IHS) may include a memory having program instructions stored thereon that, upon execution, cause the IHS to: receive a control operation from a first user wearing a first head-mounted display (HMD) during a collaborative xR session with a second user, where the second user is wearing a second HMD, and is located remotely with respect to the first user; encode the control operation using a first encoding method; receive a workspace operation from the first user; encode the workspace operation using a second encoding method; aggregate the encoded control operation with the encoded workspace operation into one or more packets; and transmit the one or more packets to the second user during the collaborative xR session.