Embodiments of the invention are directed to systems, methods and computer program products for enhanced detection of polymorphic malicious content within an entity. In this regard, the present invention receives information associated with an incidence of an electronic file; receives an first hash value of the electronic file from a first network device and a second hash value of the electronic file from a second network device; compares the first hash value with the second hash value; determines that the electronic file is polymorphic based on at least the match; initiates an execution of a quantum optimization algorithm using a quantum optimizer to determine one or more hash value states; receive information associated with an incidence of the electronic file at the third network device; determine that the electronic file is malware; and initiate an intrusion detection protocol configured to deny the electronic file access to the third network device.