- 专利标题： Inhibitors of adenosine 5′-nucleotidase
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申请号： US16338975申请日： 2017-10-02
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公开(公告)号： US11058704B2公开(公告)日： 2021-07-13
- 发明人: Laurent Pierre Paul Debien , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
- 申请人： ARCUS BIOSCIENCES, INC.
- 申请人地址： US CA Hayward
- 专利权人： ARCUS BIOSCIENCES, INC.
- 当前专利权人： ARCUS BIOSCIENCES, INC.
- 当前专利权人地址： US CA Hayward
- 代理机构： Mintz Levin Cohn Ferris Glovsky and Popeo PC
- 国际申请： PCT/US2017/054694 WO 20171002
- 国际公布： WO2018/067424 WO 20180412
- 主分类号： A01N43/04
- IPC分类号： A01N43/04 ; A61K31/70 ; A61K31/7076 ; A61K31/706 ; A61K31/7064 ; A61K39/395 ; C07H19/20 ; C07H19/207 ; C07H19/23
摘要：
Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
公开/授权文献
- US20200222441A1 INHIBITORS OF ADENOSINE 5'-NUCLEOTIDASE 公开/授权日：2020-07-16