Systems and methods for secured access to cloud-based applications or services include a service node that may receive a request from client including a URL associated with an application manager. The service node may send a URL prefix identifying a termination to the termination node. The service node may receive a client hello message from the client that includes a first field incorporating the URL prefix, and may send the client hello message to the termination node to initiate a handshake with the client using a wildcard certificate of server, for establishing a SSL channel between the client and the termination node for a session of the application. The service node can direct a communication of the session from the client to the predetermined termination node, for decryption, using the established SSL channel, according to the URL prefix incorporated in a server name indication (SNI) field of the communication.