Invention Grant
- Patent Title: Methods of treating cardiovascular disease with an anti-ASGR antibody or binding fragments thereof
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Application No.: US16230356Application Date: 2018-12-21
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Publication No.: US11066472B2Publication Date: 2021-07-20
- Inventor: Paul Nioi , Peter Coward , Christopher Murawsky
- Applicant: Amgen Inc.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Main IPC: A61P9/10
- IPC: A61P9/10 ; A61P3/06 ; A61K39/395 ; C07K16/28 ; A61P9/04 ; C12N15/113 ; C07H21/02 ; A61K45/06 ; C07K14/705 ; A61K39/00
Abstract:
Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.
Public/Granted literature
- US20190248902A1 ASGR INHIBITORS Public/Granted day:2019-08-15
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