Empirically modulated antenna systems and related methods are disclosed herein. An empirically modulated antenna system includes an antenna and a controller programmed to control the antenna. The antenna includes a plurality of discrete scattering elements arranged in a one- or two-dimensional arrangement. A method includes modulating operational states of at least a portion of a plurality of discrete scattering elements of the antenna in a plurality of different modulation patterns. The plurality of different modulation patterns includes different permutations of the discrete scattering elements operating in different operational states. The method also includes evaluating a performance parameter of the antenna responsive to the plurality of different empirical one- or two-dimensional modulation patterns. The method further includes operating the antenna in one of the plurality of different one- or two-dimensional empirical modulation patterns selected based, at least in part, on the performance parameter.