- 专利标题： Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
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申请号： US16598661申请日： 2019-10-10
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公开(公告)号： US11077180B2公开(公告)日： 2021-08-03
- 发明人: Annaliesa Sybil Anderson , Kathrin Ute Jansen , Mark Edward Ruppen , Justin Keith Moran , Susan Kay Hoiseth
- 申请人： Wyeth LLC
- 申请人地址： US NY New York
- 专利权人： Wyeth LLC
- 当前专利权人： Wyeth LLC
- 当前专利权人地址： US NY New York
- 代理商 Matthew J. Pugmire
- 主分类号： A61K39/095
- IPC分类号： A61K39/095 ; C07K14/22 ; C07K16/12 ; A61K39/00
摘要：
The present invention relates to compositions including an isolated non-pyruvylated non-lipidated ORF2086 polypeptide, and methods thereof. In an exemplary embodiment, the compositions described herein are immunogenic. The present invention further relates to compositions that elicit a bactericidal immune response in a mammal against an ORF2086 subfamily B polypeptide from serogroup B Neisseria meningitidis, and methods related thereto.
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