- 专利标题： Compounds and methods for inhibiting EMT pathways to treat cancer, organ fibrosis and metabolic disorders
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申请号： US16487770申请日： 2018-02-19
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公开(公告)号： US11078159B2公开(公告)日： 2021-08-03
- 发明人: Abdelhadi Rebbaa , Sebastien Comesse , Adam Daich , Martin Lawson , Catalin Pintiala
- 申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education , Universite Le Havre Normandie
- 申请人地址： US PA Pittsburgh; FR Le Havre
- 专利权人： University of Pittsburgh—Of the Commonwealth System of Higher Education,Universite Le Havre Normandie
- 当前专利权人： University of Pittsburgh—Of the Commonwealth System of Higher Education,Universite Le Havre Normandie
- 当前专利权人地址： US PA Pittsburgh; FR Le Havre
- 代理机构： Kalrquist Sparkman, LLP
- 国际申请： PCT/US2018/018647 WO 20180219
- 国际公布： WO2018/156459 WO 20180830
- 主分类号： C07D213/02
- IPC分类号： C07D213/02 ; A61P35/00
摘要：
A compound, or a pharmaceutically acceptable salt or isomer thereof, of Formula I: wherein R is hydrogen, alkyl, substituted alkyl, alkenyl, or substituted alkenyl; R1 is hydrogen, alkoxy, or substituted alkoxy; R2 is hydrogen, alkyl, or substituted alkyl; and R3 is hydrogen, alkyl, or substituted alkyl.
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