- 专利标题： Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
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申请号： US15117146申请日： 2015-02-05
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公开(公告)号： US11078193B2公开(公告)日： 2021-08-03
- 发明人: Koen Vandyck , Geerwin Yvonne Paul Haché , Stefaan Julien Last , Geert Rombouts , Wim Gaston Verschueren , Pierre Jean-Marie Bernard Raboisson
- 申请人： Janssen Sciences Ireland UC
- 申请人地址： IE Little Island, Co Cork
- 专利权人： Janssen Sciences Ireland UC
- 当前专利权人： Janssen Sciences Ireland UC
- 当前专利权人地址： IE Little Island, Co Cork
- 优先权： EP14154167 20140206,EP14169438 20140522,EP14177505 20140717,EP14193926 20141119
- 国际申请： PCT/EP2015/052389 WO 20150205
- 国际公布： WO2015/118057 WO 20150813
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; A61K31/4439 ; C07D405/14 ; A61K31/4545 ; A61K45/06 ; C07D401/14
摘要：
Inhibitors of HBV replication of Formula (A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R5 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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