An ultrasound imaging system includes a transducer array configured to transmit an ultrasound pressure field and receive an echo pressure field for a contrast-enhanced scan, and generate an electrical signal indicative of the received echo pressure field. The system further includes a signal processor configured to process the electrical signal and generate at least contrast enhanced ultrasound (CEUS) data indicative of nonlinear signal in the electrical signal. The system further includes a microbubble processor configured to process the CEUS data and generate microbubble data based on a predetermined contrast-agent microbubble size, shape and adjacency for microbubbles of interest. The system further includes a display configured to display a microbubble image indicative of the microbubble data.