A medical mattress for temporarily receiving a bed pan for use by a patient, comprising a mattress body of hospital grade mattress foam having a mattress cavity therein. Removable interior and exterior mattress inserts fit in the mattress cavity. The interior insert can be replaced by a bed pan. Hand grips on the interior and exterior inserts assist with removal and replacement of the inserts. Interlock fasteners are provided for temporarily securing the interior and exterior inserts in the mattress cavity for support of the patient. Methods of using and making the mattress are provided.