Implementations of the disclosure describe systems and methods that leverage machine learning to automate the process of creating music and effects mixes from original sound mixes including domestic dialogue. In some implementations, a method includes: receiving a sound mix including human dialogue; extracting metadata from the sound mix, where the extracted metadata categorizes the sound mix; extracting content feature data from the sound mix, the extracted content feature data including an identification of the human dialogue and instances or times the human dialogue occurs within the sound mix; automatically calculating, with a trained model, content feature data of a music and effects (M&E) sound mix using at least the extracted metadata and the extracted content feature data of the sound mix; and deriving the M&E sound mix using at least the calculated content feature data.