A method based on fluidizing for modifying and preparing low-cost titanium powders for 3D printing includes: using hydrogenated-dehydrogenated irregularly-shaped titanium powders as the raw material, adding the titanium powders to a fluidized bed reactor, and introducing Ar or H2 at the flow rate of 0.5-1.5 L/min, heating the reactor to 300-700° C., and fluidizing for 5-90 min to modify the titanium powders. When filled with high-purity argon gas and heated at high temperature, the sharp edges and corners of irregularly-shaped titanium powders are ground collision of the particles due to the friction among powder particles.