The disclosure provides a method and a device in a User Equipment (UE) and a base station for wireless communication. The UE first receives a first signaling, the first signaling indicating to transmit a first bit block in a first time-frequency resource block, then receives a second signaling, the second signaling indicating to transmit a second bit block in a second time-frequency resource block, and finally transmits a second radio signal in the second time-frequency resource block; the second bit block is used for generating the second radio signal; the first bit block includes a first bit subblock and a second bit subblock; the transmission mode in the first time-frequency resource block is associated with a relationship between an end time of time-frequency resources in the first time-frequency resource block assigned to the first bit subblock and a start time of the second time-frequency resource block.