The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, a normalization device is configured to facilitate normalization of medical images of a coronary region of a subject for an algorithm-based medical imaging analysis. The normalization device can include a substrate and a plurality of compartments positioned within the substrate, each of the plurality of compartments configured to hold a sample of a known material. A first subset of the plurality of compartments can hold at least one sample of a contrast material, a second subset of the plurality of compartments can hold samples of materials representative of materials to be analyzed by the algorithm-based medical imaging analysis, and a third subset of the plurality of compartments hold at least one sample of a phantom material.